Activation of hepatic estrogen receptor-α increases energy expenditure by stimulating the production of fibroblast growth factor 21 in female mice

@inproceedings{Allard2019ActivationOH,
  title={Activation of hepatic estrogen receptor-α increases energy expenditure by stimulating the production of fibroblast growth factor 21 in female mice},
  author={Camille Allard and Fabrice Bonnet and Beibei Xu and Laurel Aubrie Coons and Diana C. Albarado and Christopher Mark Hill and Guy Fagherazzi and Kenneth S. Korach and Ellis Robert Levin and John Lefante and Christopher D Morrison and Franck Mauvais-Jarvis},
  booktitle={Molecular metabolism},
  year={2019}
}
OBJECTIVE The endogenous estrogen 17β-estradiol (E2) promotes metabolic homeostasis in premenopausal women. In a mouse model of post-menopausal metabolic syndrome, we reported that estrogens increased energy expenditure, thus preventing estrogen deficiency-induced adiposity. Estrogens' prevention of fat accumulation was associated with increased serum concentrations of fibroblast growth factor 21 (FGF21), suggesting that FGF21 participates in estrogens' promotion of energy expenditure… CONTINUE READING
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