Activation of hemostasis during cardiopulmonary bypass and pediatric aprotinin dosage.

@article{Mssinger1998ActivationOH,
  title={Activation of hemostasis during cardiopulmonary bypass and pediatric aprotinin dosage.},
  author={Hansj{\"o}rg M{\"o}ssinger and Wulf Dietrich},
  journal={The Annals of thoracic surgery},
  year={1998},
  volume={65 6 Suppl},
  pages={
          S45-50; discussion S50-1, S74-6
        }
}
BACKGROUND Cardiopulmonary bypass results in inappropriate activation of the coagulation and fibrinolytic systems. Factors such as a greater degree of hemodilution, use of deep hypothermic circulatory arrest, the impact of cyanosis on coagulation, and the immature coagulation system of the newborn will increase the risk of problematic perioperative bleeding. METHODS This article describes the characteristics of the hemostatic system in children undergoing cardiac operations and addresses the… CONTINUE READING

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