Activation of heat-shock transcription factor by graded reductions in renal ATP, in vivo, in the rat.

@article{Why1994ActivationOH,
  title={Activation of heat-shock transcription factor by graded reductions in renal ATP, in vivo, in the rat.},
  author={Scott K. Van Why and Andrea S. Mann and Gunilla E Thulin and Xin Hao Zhu and Michael Kashgarian and Norman Joseph Siegel},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={94 4},
  pages={1518-23}
}
Renal ischemia results in both a profound fall in cellular ATP and a rapid induction of the 70 kD heat-shock protein family, HSP-70. The present studies examined the relationship between cellular ATP and induction of the stress response in renal cortex. Cellular ATP, continuously monitored by in vivo 31P-NMR spectroscopy, was reduced and maintained at specific, stable levels in renal cortex by partial aortic occlusion for 45 min. Activation of heat-shock transcription factor (HSF) was detected… CONTINUE READING