Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty.

@article{Han2005ActivationOG,
  title={Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty.},
  author={Seong-Kyu Han and Michelle L. Gottsch and Kathy J. Lee and Simina M. Popa and Jeremy T. Smith and Sonya Kee Yun Jakawich and Donald K. Clifton and Robert A Steiner and Allan E Herbison},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 49},
  pages={
          11349-56
        }
}
We examined the role of kisspeptin and its receptor, the G-protein-coupled receptor GPR54, in governing the onset of puberty in the mouse. In the adult male and female mouse, kisspeptin (10-100 nM) evoked a remarkably potent, long-lasting depolarization of >90% of gonadotropin-releasing hormone (GnRH)-green fluorescent protein neurons in situ. In contrast, in juvenile [postnatal day 8 (P8) to P19] and prepubertal (P26-P33) male mice, kisspeptin activated only 27 and 44% of GnRH neurons… CONTINUE READING

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