Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments.

@article{Zhu2007ActivationOG,
  title={Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments.},
  author={Ling-Qiang Zhu and Shao-hui Wang and Dan Liu and Yuqin Yin and Q. I. Tian and Xiao-Chuan Wang and Qun Wang and Jingxian Chen and Jeffrey Wang},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 45},
  pages={
          12211-20
        }
}
Activation of glycogen synthase kinase-3 (GSK-3) can cause memory deficits as seen in Alzheimer's disease, the most common age-associated dementia, but the mechanism is not understood. Here, we found that activation of GSK-3 by wortmannin or transient overexpression of wild-type GSK-3beta could suppress the induction of long-term potentiation (LTP) in rat hippocampus, whereas simultaneous inhibition of GSK-3 by lithium or SB216763 or transient expression of a dominant-negative GSK-3beta mutant… CONTINUE READING

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Glycogen synthase kinase-3 inhibition is integral to long-term potentiation

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  • Eur J Neurosci
  • 2007

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