Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease

@article{DaRochaSouto2012ActivationOG,
  title={Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease},
  author={Bibiana DaRocha-Souto and Mireia Coma and Beatriz Gomez Perez-Nievas and Thomas C. Scotton and Teresa G{\'o}mez-Isla},
  journal={Neurobiology of Disease},
  year={2012},
  volume={45},
  pages={425-437}
}
β-Amyloid (Aβ) plaques in Alzheimer (AD) brains are surrounded by severe dendritic and axonal changes, including local spine loss, axonal swellings and distorted neurite trajectories. Whether and how plaques induce these neuropil abnormalities remains unknown. We tested the hypothesis that oligomeric assemblies of Aβ, seen in the periphery of plaques, mediate the neurodegenerative phenotype of AD by triggering activation of the enzyme GSK-3β, which in turn appears to inhibit a transcriptional… CONTINUE READING

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