• Biology, Medicine
  • Published in Journal of immunology 1995

Activation of gamma delta T cells for production of IFN-gamma is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12.

@article{Skeen1995ActivationOG,
  title={Activation of gamma delta T cells for production of IFN-gamma is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12.},
  author={Marianne J. Skeen and Hans K. Ziegler},
  journal={Journal of immunology},
  year={1995},
  volume={154 11},
  pages={
          5832-41
        }
}
Gamma delta T cells are found at sites of microbial infection and have been reported to proliferate in response to bacterial Ags. We show here that although the response by Listeria-elicited peritoneal gamma delta T cells to heat-killed bacteria in the presence of macrophage accessory cells may be partially mediated via the TCR, it is predominantly mediated via cytokines produced by the macrophages. Macrophage cytokines IL-12 and IL-1 synergize to induce some proliferation and considerable IFN… CONTINUE READING

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