Activation of fibroblast metabolism in a dermal and skin equivalent model: a screening test for activity of peptides.

@article{Frei1998ActivationOF,
  title={Activation of fibroblast metabolism in a dermal and skin equivalent model: a screening test for activity of peptides.},
  author={V T Frei and Eric Perrier and Isabelle Orly and Angelica Huc and Cupşa Augustin and Odile Damour},
  journal={International journal of cosmetic science},
  year={1998},
  volume={20 3},
  pages={159-73}
}
Skin firmness, elasticity and tone are gradually lost with age. These changes originate in the dermis and correspond to a decrease in the ability of cells, particularly the fibroblasts, to regenerate the molecules which make up the extracellular matrix. Skin ageing is also characterized by a reduction of the epidermal thickness and by a flattening of the basal membrane. The recent development of two 3-dimensional culture systems, in which the cells develop within a porous structure reproducing… CONTINUE READING