Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- mice.

@article{Hartman2009ActivationOF,
  title={Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- mice.},
  author={Helen B Hartman and Stephen J. Gardell and Chris J Petucci and Shuguang Wang and Julie A Krueger and Mark J. Evans},
  journal={Journal of lipid research},
  year={2009},
  volume={50 6},
  pages={1090-100}
}
The role of farnesoid X receptor (FXR) in the development of atherosclerosis has been unclear. Here, LDL receptor (LDLR(-/-)) or apolipoprotein E (apoE(-/-)) female or male mice were fed a Western diet and treated with a potent synthetic FXR agonist, WAY-362450. Activation of FXR blocked diet-induced hypertriglyceridemia and elevations of non-HDL cholesterol and produced a near complete inhibition of aortic lesion formation. WAY-362450 also induced small heterodimer partner (SHP) expression and… CONTINUE READING
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