Activation of extrathymic T cells in the liver and reciprocal inactivation of intrathymic T cells by bacterial stimulation.

@article{Abo1992ActivationOE,
  title={Activation of extrathymic T cells in the liver and reciprocal inactivation of intrathymic T cells by bacterial stimulation.},
  author={Toru Abo and Akihiro Kusumi and Shuhji Seki and Toshiaki Ohteki and Kikuya Sugiura and Tohru Masuda and Hidemi Rikiishi and Tsuneo Iiai and Kotaro Kumagai},
  journal={Cellular immunology},
  year={1992},
  volume={142 1},
  pages={125-36}
}
We recently demonstrated that the liver might be a major site of extrathymic T cell differentiation, including both alpha beta and gamma delta T cells. This extrathymic pathway in the liver, which has a relatively minor role in normal young mice, is activated in mice under bacterial stimulation. In the present study, we investigated how the extrathymic and intrathymic T cell differentiations were mutually related in mice injected intravenously with 10(8) heat-killed Escherichia coli. Three days… CONTINUE READING

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