Activation of extrasynaptic NMDA receptors induces LTD in rat hippocampal CA1 neurons

@article{Liu2013ActivationOE,
  title={Activation of extrasynaptic NMDA receptors induces LTD in rat hippocampal CA1 neurons},
  author={D. Liu and Q. Yang and Sheng-tian Li},
  journal={Brain Research Bulletin},
  year={2013},
  volume={93},
  pages={10-16}
}
In the adult rat hippocampus, activation of N-methyl-d-aspartate receptors (NMDARs) is required for the induction of certain forms of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). Several studies have indicated the opposing role of synaptic NMDARS (S-NMDARs) versus extrasynaptic NMDARs (ES-NMDARs) in CREB-dependent gene regulation and neuronal survival/death. The contribution of ES-NMDARs in synaptic plasticity, however, remains unclear. Here we… Expand
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