Activation of extracellular signal-regulated kinase mediates bombesin-induced mitogenic responses in prostate cancer cells.

@article{Xiao2003ActivationOE,
  title={Activation of extracellular signal-regulated kinase mediates bombesin-induced mitogenic responses in prostate cancer cells.},
  author={Dongmei Xiao and Xiangping Qu and Horst Christian Weber},
  journal={Cellular signalling},
  year={2003},
  volume={15 10},
  pages={945-53}
}
Bombesin and its mammalian homologue gastrin-releasing peptide have been shown to be highly expressed and secreted by neuroendocrine cells in prostate cancer, and are thought to be related to the carcinogenesis and progression of this disease. We found, in this study, bombesin specifically induced mitogen-activated protein (MAP) kinase activation as shown by increased extracellular regulated kinase (ERK) phosphorylation and epidermal growth factor (EGF) receptor transactivation in prostate… CONTINUE READING