Activation of extracellular signal-regulated protein kinase in sensory neurons after noxious gastric distention and its involvement in acute visceral pain in rats.

@article{Sakurai2008ActivationOE,
  title={Activation of extracellular signal-regulated protein kinase in sensory neurons after noxious gastric distention and its involvement in acute visceral pain in rats.},
  author={Jun Sakurai and Koichi Obata and Noriyuki Ozaki and Atsushi Tokunaga and Kimiko Kobayashi and Hiroki Yamanaka and Yi Dai and Takashi Kondo and Kan Miyoshi and Yasuo Sugiura and Takayuki Matsumoto and Hiroto Miwa and Koichi Noguchi},
  journal={Gastroenterology},
  year={2008},
  volume={134 4},
  pages={1094-103}
}
BACKGROUND & AIMS Changes in the properties of visceral sensory neurons contribute to the development of gastrointestinal pain. However, little is known about the molecules involved in mechanosensation from the gastrointestinal tract. We investigated the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), a member of the mitogen-activated protein kinase cascade, in dorsal root ganglion (DRG) and nodose ganglion (NG) neurons by noxious gastric distention (GD) and its… CONTINUE READING
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