Activation of extracellular signal-regulated kinase 1/2 inhibits type I collagen expression by human skin fibroblasts.

@article{Reunanen2000ActivationOE,
  title={Activation of extracellular signal-regulated kinase 1/2 inhibits type I collagen expression by human skin fibroblasts.},
  author={Niina Reunanen and Marco Foschi and Jiahuai Han and V M Kahari},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 44},
  pages={34634-9}
}
Treatment with the lipid second messenger, ceramide, activates extracellular signal-regulated kinase-1/2 (ERK1/2), c-Jun N-terminal kinase, and p38 in human skin fibroblasts and induces their collagenase-1 expression (Reunanen, N., Westermarck, J., Häkkinen, L., Holmström, T. H., Elo, I., Eriksson, J. E., and Kähäri, V.-M. (1998) J. Biol. Chem. 273, 5137-5145). Here we show that C(2)-ceramide inhibits expression of type I and III collagen mRNAs in dermal fibroblasts, suppresses proalpha2(I… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…