Activation of extracellular signal-regulated kinase (ERK) and p38 kinase in shock wave-promoted bone formation of segmental defect in rats.

@article{Chen2004ActivationOE,
  title={Activation of extracellular signal-regulated kinase (ERK) and p38 kinase in shock wave-promoted bone formation of segmental defect in rats.},
  author={Yeung-Jen Chen and Y R Kuo and Kuender D. Yang and C J Wang and Shyr-Ming Sheen Chen and Hui-Chen Huang and Ya-Ju Yang and Sun Yi-Chih and F. S. Wang},
  journal={Bone},
  year={2004},
  volume={34 3},
  pages={466-77}
}
Extracorporeal shock waves (ESW) have recently been used in bone repair. Extracellular signal-regulated kinase (ERK) and p38 kinase are found to act as important mediators for osteogenic factor and mechanical-stimulated proliferation and differentiation of bone-forming cells. A previous study reported that ESW promoted healing of segmental defects in rats by inducing bone morphogenetic proteins (Bone 32 (2003) 387-396) and stimulating osteogenic differentiation of mesenchymal stem cells. In… CONTINUE READING

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