Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations

@article{Schmitz2006ActivationOE,
  title={Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations},
  author={Klaus Juergen Schmitz and Jeremias Wohlschlaeger and Hakan Alakus and Johan Bohr and Monica Stauder and Karl Worm and G{\"u}nther Winde and Kurt Werner Schmid and Hideo Baba},
  journal={Virchows Archiv},
  year={2006},
  volume={450},
  pages={151-159}
}
Signal transduction and modulation represent central mechanisms in cellular processes such as cell-cycle regulation, oncogenesis, and apoptosis. The aim of this study was to determine the prognostic relevance of two kinases important in the regulation of cell proliferation and apoptosis in 135 colorectal cancer cases: AKT and extracellular regulated kinases (ERK1/2). We investigated the relationship of phospho-ERK1/2 (pERK1/2) and phospho-AKT (pAKT) with associated parameters (EGFR, COX-2… CONTINUE READING
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