Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine.

@article{Tatulian2001ActivationOE,
  title={Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine.},
  author={Lucine Tatulian and Patrick Delmas and Fe C. Abogadie and David A. Brown},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 15},
  pages={
          5535-45
        }
}
Retigabine [D-23129; N-(2-amino-4-(4-fluorobenzylamino)-phenyl) carbamic acid ethyl ester] is a novel anticonvulsant compound that is now in clinical phase II development. It has previously been shown to enhance currents generated by KCNQ2/3 K(+) channels when expressed in Chinese hamster ovary (CHO) cells (Main et al., 2000; Wickenden et al., 2000). In the present study, we have compared the actions of retigabine on KCNQ2/3 currents with those on currents generated by other members of the KCNQ… CONTINUE READING

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References

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Single-channel analysis of KCNQ2/3 potassium currents expressed in mammalian (CHO) cells

AA Selyanko, JK Hadley, DA Brown
  • Soc Neurosci Abstr
  • 2000
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL