Activation of erythropoietin signaling by receptor dimerization.

@article{Watowich1999ActivationOE,
  title={Activation of erythropoietin signaling by receptor dimerization.},
  author={Stephanie S Watowich},
  journal={The international journal of biochemistry & cell biology},
  year={1999},
  volume={31 10},
  pages={
          1075-88
        }
}
The hormone erythropoietin (Epo) is essential for red blood cell development. Epo binds a high affinity receptor on the surface of erythroid progenitor cells, stimulating receptor dimerization and activation of the intracellular signal transduction pathways that support erythroid cell survival, proliferation and differentiation. Biochemical and structural analysis of the erythropoietin receptor (EpoR) is revealing the molecular mechanisms of EpoR function, leading the way to the development of… CONTINUE READING

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