Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes.

@article{Southall2003ActivationOE,
  title={Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes.},
  author={Michael D. Southall and Tao Li and Lera S Gharibova and Yong Pei and Grant D. Nicol and Jeffrey B Travers},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={304 1},
  pages={217-22}
}
During dermal injury and the associated trauma a number of compounds are released that can mediate the inflammatory response. Determining the cellular mechanisms that initiate the inflammatory responses to acute keratinocyte damage is important for understanding the regulation of epidermal inflammation. The recently cloned vanilloid receptor-1 (VR1) is a polymodal receptor, responding to thermal, pH, or vanilloids such as capsaicin stimulation. Although VR1 has been localized only on sensory… CONTINUE READING
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