Activation of epidermal toll-like receptor 2 enhances tight junction function – Implications for atopic dermatitis and skin barrier repair

@inproceedings{Kuo2013ActivationOE,
  title={Activation of epidermal toll-like receptor 2 enhances tight junction function – Implications for atopic dermatitis and skin barrier repair},
  author={I-Hsin Kuo and Amanda Carpenter-Mendini and Takeshi Yoshida and Laura Y. McGirt and Andrei I. Ivanov and Kathleen Carole Barnes and Richard L Gallo and Andrew W. Borkowski and Kenshi Yamasaki and Donald Y. M. Leung and Steve N. Georas and Anna de Benedetto and Lisa A. Beck},
  booktitle={The Journal of investigative dermatology},
  year={2013}
}
Atopic dermatitis (AD) is characterized by epidermal tight junction (TJ) defects and a propensity for Staphylococcus aureus skin infections. S. aureus is sensed by many pattern recognition receptors, including Toll-like receptor 2 (TLR2). We hypothesized that an effective innate immune response will include skin barrier repair, and that this response is impaired in AD subjects. S. aureus-derived peptidoglycan (PGN) and synthetic TLR2 agonists enhanced TJ barrier and increased expression of TJ… CONTINUE READING
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