Activation of epidermal growth factor receptor signaling by the prostaglandin E(2) receptor EP4 pathway during gastric tumorigenesis.

@article{Oshima2011ActivationOE,
  title={Activation of epidermal growth factor receptor signaling by the prostaglandin E(2) receptor EP4 pathway during gastric tumorigenesis.},
  author={Hiroko Oshima and Boryana Konstantinova Popivanova and Keisuke Oguma and Dan Kong and Tomo-o Ishikawa and Masanobu Oshima},
  journal={Cancer science},
  year={2011},
  volume={102 4},
  pages={713-9}
}
Cyclooxygenase-2 (COX-2) plays an important role in tumorigenesis through prostaglandin E(2) (PGE(2)) biosynthesis. It has been shown by in vitro studies that PGE(2) signaling transactivates epidermal growth factor receptor (EGFR) through an intracellular mechanism. However, the mechanisms underlying PGE(2)-induced EGFR activation in in vivo tumors are still not fully understood. We previously constructed transgenic mice that develop gastric tumors caused by oncogenic activation and PGE(2… CONTINUE READING

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