Activation of endothelial nitric oxide synthase by the angiotensin II type 1 receptor.

@article{Suzuki2006ActivationOE,
  title={Activation of endothelial nitric oxide synthase by the angiotensin II type 1 receptor.},
  author={Hiroyuki Suzuki and Kunie Eguchi and Haruhiko Ohtsu and Sadaharu Higuchi and Sudhir Dhobale and Gerald Frank and Evangeline D. Motley and Satoru Eguchi},
  journal={Endocrinology},
  year={2006},
  volume={147 12},
  pages={5914-20}
}
Enhanced angiotensin II (AngII) action has been implicated in endothelial dysfunction that is characterized as decreased nitric oxide availability. Although endothelial cells have been reported to express AngII type 1 (AT1) receptors, the exact role of AT1 in regulating endothelial NO synthase (eNOS) activity remains unclear. We investigated the possible regulation of eNOS through AT1 in bovine aortic endothelial cells (BAECs) and its functional significance in rat aortic vascular smooth muscle… CONTINUE READING
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