Activation of endothelial BKCa channels causes pulmonary vasodilation.

  title={Activation of endothelial BKCa channels causes pulmonary vasodilation.},
  author={Alexander Vang and Jeffrey M Mazer and Brian P Casserly and Gaurav Choudhary},
  journal={Vascular pharmacology},
  volume={53 3-4},
BACKGROUND Large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels cause hyperpolarization and can regulate vascular tone. In this study, we evaluated the effect of endothelial BK(Ca) activation on pulmonary vascular tone. METHODS The presence of BK(Ca) channels in lung microvascular endothelial cells (LMVEC) and rat lung tissue was confirmed by RT-PCR, immunoblotting and immunohistochemistry. Isolated pulmonary artery (PA) rings and isolated ventilated-perfused rat lungs were used to assay… CONTINUE READING
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