Activation of endogenous protein kinase C by halothane in synaptosomes.

  title={Activation of endogenous protein kinase C by halothane in synaptosomes.},
  author={Hugh C Hemmings and Anna I B Adamo},
  volume={84 3},
BACKGROUND Protein kinase C is a signal transducing enzyme that is an important regulator of multiple physiologic processes and a potential molecular target for general anesthetic actions. However, the results of previous studies of the effects of general anesthetics on protein kinase C activation in vitro have been inconsistent. METHODS The effects of halothane on endogenous brain protein kinase C activation were analyzed in isolated rat cerebrocortical nerve terminals (synaptosomes) and in… CONTINUE READING


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