Activation of endogenous Cdc42 visualized in living cells.

@article{Nalbant2004ActivationOE,
  title={Activation of endogenous Cdc42 visualized in living cells.},
  author={Perihan Nalbant and Louis Hodgson and Vadim S Kraynov and Alexei Toutchkine and Klaus Michael Hahn},
  journal={Science},
  year={2004},
  volume={305 5690},
  pages={1615-9}
}
Signaling proteins are tightly regulated spatially and temporally to perform multiple functions. For Cdc42 and other guanosine triphosphatases, the subcellular location of activation is a critical determinant of cell behavior. However, current approaches are limited in their ability to examine the dynamics of Cdc42 activity in living cells. We report the development of a biosensor capable of visualizing the changing activation of endogenous, unlabeled Cdc42 in living cells. With the use of a… CONTINUE READING
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