Activation of early silent synapses by spontaneous synchronous network activity limits the range of neocortical connections.

@article{Voigt2005ActivationOE,
  title={Activation of early silent synapses by spontaneous synchronous network activity limits the range of neocortical connections.},
  author={Thomas Voigt and Thoralf Opitz and Ana Dolabela de Lima},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 18},
  pages={4605-15}
}
During the early development of neocortical networks, many glutamatergic synapses lack AMPA receptors and are physiologically silent. We show in neocortical cultures that spontaneous synchronous network activity is able to convert silent synapses to active synapses by the incorporation of AMPA receptors into synaptic complexes throughout the network within a few minutes. To test the effect of synaptic activation on the connectivity of neuronal populations, we created separated neuronal networks… CONTINUE READING

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References

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Showing 1-10 of 40 references

Activation of silent synapses by rapid activity-dependent synaptic recruitment of AMPA receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2001
View 5 Excerpts
Highly Influenced

Silent synapses in the developing rat visual cortex: evidence for postsynaptic expression of synaptic plasticity.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1998
View 6 Excerpts
Highly Influenced

Synchronization of calcium activity promotes survival of individual rat neocortical neurons in early development

T Voigt, H Baier, AD de Lima
Eur J Neurosci • 1997
View 4 Excerpts
Highly Influenced

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