Activation of early signaling transcription factor, NF-kappaB following low-level manganese exposure.

@article{Ramesh2002ActivationOE,
  title={Activation of early signaling transcription factor, NF-kappaB following low-level manganese exposure.},
  author={Govindarajan T. Ramesh and Debabrata Ghosh and Palur G Gunasekar},
  journal={Toxicology letters},
  year={2002},
  volume={136 2},
  pages={151-8}
}
Occupational and environmental exposure to manganese (Mn(2+)) is an increasing problem. It manifests neuronal degeneration characterized by dyskinesia resembling Parkinson's disease. The study was performed to test the hypotheses whether exposure to Mn(2+) alters cellular physiology and promotes intracellular signaling mechanism in dopaminergic neuronal cell line. Since transcription factors have been shown to play an essential role in the control of cellular proliferation and survival… CONTINUE READING

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