Activation of early gene transcription in polyomavirus BK by human immunodeficiency virus type 1 Tat.

@article{Gorrill2006ActivationOE,
  title={Activation of early gene transcription in polyomavirus BK by human immunodeficiency virus type 1 Tat.},
  author={Timothy S Gorrill and Mariha Feliciano and Ruma Mukerjee and Bassel E. Sawaya and Kamel Khalili and Martyn K. White},
  journal={The Journal of general virology},
  year={2006},
  volume={87 Pt 6},
  pages={1557-66}
}
Polyomavirus BK (BKV) is a serious problem for immunocompromised patients, where latent virus can enter into the lytic cycle causing cytolytic destruction of host cells. BKV infects >80% of the population worldwide during childhood and then remains in a latent state in the kidney. In the context of immunosuppression in kidney transplant patients, reactivation of the viral early promoter (BKV(E)) results in production of T antigen, enabling virus replication and transition from latency to the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Exposure Data 1 . 1 Cell and tissue tropism

BK POLYOMAVIRUS
2013
View 1 Excerpt

The human polyomavirus BK (BKPyV): virological background and clinical implications.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…