Activation of dorsal periaqueductal gray by glycine produces long lasting hyponociception in rats without overt defensive behaviors.

@article{Martins2008ActivationOD,
  title={Activation of dorsal periaqueductal gray by glycine produces long lasting hyponociception in rats without overt defensive behaviors.},
  author={Maria Alcina Martins and Antonio de P{\'a}dua Carobrez and Carlos Rog{\'e}rio Tonussi},
  journal={Life sciences},
  year={2008},
  volume={83 3-4},
  pages={118-21}
}
Electrical or glutamate stimulation of the dorsal periaqueductal gray matter (DPAG) of rats induces overt defensive behavior, such as freezing or flight, and hyponociception, while glycine and D-serine, a specific NMDA/GLY(B)-site ligand, produced only subtle defensive behavior related to risk assessment and avoidance from the open arms in the elevated plus-maze test. In order to verify whether the GLY(B) site in the DPAG could also be involved in hyponociception, glycine (GLY; 10, 20, 50, and… CONTINUE READING

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