Activation of dopamine D2 receptors simultaneously ameliorates various metabolic features of obese women.

@article{Kok2006ActivationOD,
  title={Activation of dopamine D2 receptors simultaneously ameliorates various metabolic features of obese women.},
  author={Petra A M Kok and Ferdinand Roelfsema and Marijke Fr{\"o}lich and Johannes van Pelt and Marcel P. M. Stokkel and Arend Edo Meinders and Hanno Pijl},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2006},
  volume={291 5},
  pages={E1038-43}
}
The metabolic syndrome comprises a cluster of metabolic anomalies including insulin resistance, abdominal obesity, dyslipidemia, and hypertension. Previous studies suggest that impaired dopamine D2 receptor (D2R) signaling is involved in its pathogenesis. We studied the acute effects of bromocriptine (a D2R agonist) on energy metabolism in obese women; body weight and caloric intake remained constant. Eighteen healthy, obese women (BMI 33.2 +/- 0.6 kg/m(2), mean age 37.5 +/- 1.7, range 22-51 yr… CONTINUE READING

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