Activation of dopamine D1/D5 receptors facilitates the induction of presynaptic long-term potentiation at hippocampal output synapses.

@article{Roggenhofer2010ActivationOD,
  title={Activation of dopamine D1/D5 receptors facilitates the induction of presynaptic long-term potentiation at hippocampal output synapses.},
  author={Elisabeth Roggenhofer and Pawel Fidzinski and Julia C Bartsch and Felix T. Kurz and Oded Lipa Shor and Joachim Behr},
  journal={The European journal of neuroscience},
  year={2010},
  volume={32 4},
  pages={598-605}
}
Encoding of novel information has been proposed to rely on the time-locked release of dopamine in the hippocampal formation during novelty detection. However, the site of novelty detection in the hippocampus remains a matter of debate. According to current models, the CA1 and the subiculum act as detectors and distributors of novel sensory information. Although most CA1 pyramidal neurons exhibit regular-spiking behavior, the majority of subicular pyramidal neurons fire high-frequency bursts of… CONTINUE READING

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