Activation of different lipoxygenase isozymes induces apoptosis in human erythroleukemia and neuroblastoma cells.

@article{Maccarrone2000ActivationOD,
  title={Activation of different lipoxygenase isozymes induces apoptosis in human erythroleukemia and neuroblastoma cells.},
  author={Mauro Maccarrone and Marco Ranalli and Lorenza Bellincampi and Maria Luisa Salucci and Stefania Sabatini and Gerry Melino and Alessandro Finazzi-Agr{\`o}},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={272 2},
  pages={345-50}
}
We investigated the ability of different hydroperoxides generated by lipoxygenase isozymes to induce programmed cell death (PCD) in human cells. Erythroleukemia K562 and neuroblastoma CHP100 cells were used, because they showed high basal activity of lipoxygenase. The hydroperoxides generated by 5-, 12-, or 15-lipoxygenases from linoleate, linolenate, or… CONTINUE READING