Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons.

@article{Meinke1996ActivationOD,
  title={Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons.},
  author={Andreas L. Meinke and Fariba Barahmand-pour and Stefan W{\"o}hrl and Dagmar Stoiber and Thomas Decker},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 12},
  pages={
          6937-44
        }
}
Tyrosine phosphorylation and activation of the transcription factor Stat5 occur in response to stimuli like granulocyte-macrophage colony-stimulating factor, interleukin-3, or erythropoietin that stimulate both proliferation and differentiation of hematopoietic cells. It is unclear whether Stat5 is part of a proliferative response or part of the events leading to cellular differentiation. Here we report that agents promoting differentiation but not proliferation of hematopoietic cells, like… CONTINUE READING
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