Activation of cytosolic phospholipase A2alpha in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2.

@article{Noor2008ActivationOC,
  title={Activation of cytosolic phospholipase A2alpha in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2.},
  author={Shahid Noor and Howard Goldfine and Dawn Elizabeth Tucker and Saritha V Suram and Laurel L Lenz and Shizuo Akira and Satoshi Uematsu and Milena Girotti and Joseph V. Bonventre and Kevin Breuel and David M. L. Williams and Christina C. Leslie},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 8},
  pages={
          4744-55
        }
}
Eicosanoid production by macrophages is an early response to microbial infection that promotes acute inflammation. The intracellular pathogen Listeria monocytogenes stimulates arachidonic acid release and eicosanoid production from resident mouse peritoneal macrophages through activation of group IVA cytosolic phospholipase A2 (cPLA2alpha). The ability of wild type L. monocytogenes (WTLM) to stimulate arachidonic acid release is partially dependent on the virulence factor listeriolysin O… CONTINUE READING
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