Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia.

@article{Yang2007ActivationOC,
  title={Activation of cyclin-dependent kinase 5 (Cdk5) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia.},
  author={Yan-Rui Yang and Yi He and Ying Zhang and Yi Li and Yafang Li and Yan Han and Haihao Zhu and Yun Wang},
  journal={Pain},
  year={2007},
  volume={127 1-2},
  pages={109-20}
}
Cyclin-dependent kinase 5 (Cdk5) is a unique member of the CDK family. It is predominantly expressed in postmitotic neurons and has been implicated in neuronal plasticity. The present study showed that Cdk5 and p35 were expressed in primary sensory and dorsal horn neurons, while p25, an N-terminal truncated derivative of p35, could only be detected in the dorsal horn neurons. Importantly, in the case of control rats, the p35 protein level was much higher in small- and medium-diameter DRG… CONTINUE READING