Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells.

@article{Harwell2004ActivationOC,
  title={Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells.},
  author={Richard M. Harwell and Benjamin B Mull and Donald Carl Porter and Khandan Keyomarsi},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 13},
  pages={12695-705}
}
Cyclin E, a positive regulator of the cell cycle, controls the transition of cells from G(1) to S phase. Deregulation of the G(1)-S checkpoint contributes to uncontrolled cell division, a hallmark of cancer. We have reported previously that cyclin E is overexpressed in breast cancer and such overexpression is usually accompanied by the appearance of low molecular weight isoforms of cyclin E protein, which are not present in normal cells. Furthermore, we have shown that the expression of cyclin… CONTINUE READING

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