Activation of cutaneous immune responses in complex regional pain syndrome.

  title={Activation of cutaneous immune responses in complex regional pain syndrome.},
  author={Frank Birklein and Peter D Drummond and Wenwu Li and Tanja Schlereth and Nahid Albrecht and Philip M. Finch and Linda F. Dawson and J David Clark and Wade S. Kingery},
  journal={The journal of pain : official journal of the American Pain Society},
  volume={15 5},
UNLABELLED The pathogenesis of complex regional pain syndrome (CRPS) is unresolved, but tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) are elevated in experimental skin blister fluid from CRPS-affected limbs, as is tryptase, a marker for mast cells. In the rat fracture model of CRPS, exaggerated sensory and sympathetic neural signaling stimulate keratinocyte and mast cell proliferation, causing the local production of high levels of inflammatory cytokines leading to pain behavior… CONTINUE READING


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