Activation of corticotropin-releasing factor-containing neurons in the paraventricular nucleus of the hypothalamus by interleukin-1 in the rat.


Interleukin-1 (IL-1) alpha was injected into the lateral ventricle of the rat. An antiserum against Fos oncoprotein was used to detect the activated neurons immunohistochemically. A large number of neurons in the parvocellular paraventricular nucleus of the hypothalamus, in an area corresponding to the location of the corticotropin-releasing factor (CRF… (More)


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