Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels.

@article{Tao2008ActivationOC,
  title={Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels.},
  author={Jin Tao and Michael Earl Hildebrand and Ping Liao and Mui Cheng Liang and Gregory Ming-Yeong Tan and Shengnan Li and Terrance Preston Snutch and Tuck Wah Soong},
  journal={Molecular pharmacology},
  year={2008},
  volume={73 6},
  pages={
          1596-609
        }
}
The corticotropin-releasing factor (CRF) peptides CRF and uro-cortins 1 to 3 are crucial regulators of mammalian stress and inflammatory responses, and they are also implicated in disorders such as anxiety, depression, and drug addiction. There is considerable interest in the physiological mechanisms by which CRF receptors mediate their widespread effects, and here we report that the native CRF receptor 1 (CRFR1) endogenous to the human embryonic kidney 293 cells can functionally couple to… CONTINUE READING

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