Activation of cortical interneurons during sleep: an anatomical link to homeostatic sleep regulation?

@article{Kilduff2011ActivationOC,
  title={Activation of cortical interneurons during sleep: an anatomical link to homeostatic sleep regulation?},
  author={Thomas S Kilduff and Bruno Cauli and Dmitry Gerashchenko},
  journal={Trends in neurosciences},
  year={2011},
  volume={34 1},
  pages={10-9}
}
Although slow wave activity in the EEG has been linked to homeostatic sleep regulation, the neurobiological substrate of sleep homeostasis is not well understood. Whereas cortical neurons typically exhibit reduced discharge rates during slow wave sleep (SWS), a subpopulation of GABAergic interneurons, which express the enzyme neuronal nitric oxide synthase (nNOS), has recently been found to be activated during SWS. The extent of activation of these nNOS neurons is proportional to homeostatic… CONTINUE READING

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