Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels.

Abstract

The conventional kinesin motor transports many different cargos to specific locations in neurons. How cargos regulate motor function remains unclear. Here we focus on KIF5, the heavy chain of conventional kinesin, and report that the Kv3 (Shaw) voltage-gated K(+) channel, the only known tetrameric KIF5-binding protein, clusters and activates KIF5 motors… (More)
DOI: 10.1242/jcs.122234

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