Activation of constitutive nitric oxide synthases by oxidized calmodulin mutants.

@article{Montgomery2003ActivationOC,
  title={Activation of constitutive nitric oxide synthases by oxidized calmodulin mutants.},
  author={Heather J. Montgomery and Ryan K. Bartlett and Basil Perdicakis and Eric Jervis and Thomas C Squier and J Guy Guillemette},
  journal={Biochemistry},
  year={2003},
  volume={42 25},
  pages={7759-68}
}
Several calmodulin (CaM) mutants were engineered in an effort to identify the functional implications of the oxidation of individual methionines in CaM on the activity of the constitutive isoforms of nitric oxide synthase (NOS). Site-directed mutagenesis was used to substitute the majority of methionines with leucines. Substitution of all nine methionine residues in CaM with leucines had minimal effects on the binding affinity or maximal enzyme activation for either the neuronal (nNOS) or… CONTINUE READING

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