Activation of complement components and reduced regulator expression in alcohol-induced liver injury in the rat.

@article{Jrvelinen2002ActivationOC,
  title={Activation of complement components and reduced regulator expression in alcohol-induced liver injury in the rat.},
  author={Harri A. J{\"a}rvel{\"a}inen and Antti V{\"a}kev{\"a} and Kai O. Lindros and Seppo Meri},
  journal={Clinical immunology},
  year={2002},
  volume={105 1},
  pages={57-63}
}
The purpose of this study was to evaluate the possible contribution of complement-mediated inflammation to the development of alcoholic liver disease. Male Wistar rats were fed ethanol by liquid diet in a model that results in continuous ethanol intoxication and induces early signs of alcoholic liver injury. After a six-week study period liver samples were analyzed for the deposition of complement components (C1, C3, and C8) and expression of cell membrane-bound regulators (Crry and CD59… CONTINUE READING