Activation of coagulation system in preterm labor and preterm premature rupture of membranes

@article{Chaiworapongsa2002ActivationOC,
  title={Activation of coagulation system in preterm labor and preterm premature rupture of membranes},
  author={Tinnakorn Chaiworapongsa and Jimmy Espinoza and Jun Yoshimatsu and Yeon Kim and Emmanuel Bujold and Samuels Edwin and Bo Hyun Yoon and Roberto Romero},
  journal={The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians},
  year={2002},
  volume={11 6},
  pages={
          368-73
        }
}
OBJECTIVE Thrombin, originally discovered as a coagulation factor, is a multifunctional protease capable of inducing myometrial contractions in vitro and in vivo. This enzyme has been implicated in the mechanisms of premature labor. Plasma concentrations of thrombin-antithrombin (TAT) complexes are an index of in vivo thrombin generation. The purpose of this study was to determine whether patients with premature labor and preterm premature rupture of membranes (PROM) have evidence of increased… CONTINUE READING

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