Activation of coagulation and angiogenesis in cancer: immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer.

@article{Shoji1998ActivationOC,
  title={Activation of coagulation and angiogenesis in cancer: immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer.},
  author={Mitsuhiko Shoji and Wayne W Hancock and Keith Abe and Connie Micko and Katherine A Casper and R. M. Baine and Josiah N. Wilcox and I R Danave and Dirck L. Dillehay and Elizabeth Matthews and Josephine Contrino and James H Morrissey and Sharon Gordon and Thomas Scott Edgington and Bohdan Kudryk and Don L. Kreutzer and Frederick R. Rickles},
  journal={The American journal of pathology},
  year={1998},
  volume={152 2},
  pages={399-411}
}
Thrombin-catalyzed, cross-linked fibrin (XLF) formation is a characteristic histopathological finding in many human and experimental tumors and is thought to be of importance in the local host defense response. Although the pathogenesis of tumor-associated fibrin deposition is not entirely clear, several tumor procoagulants have been described as likely primary stimuli for the generation of thrombin (and XLF) in the tumor microenvironment (TME). In a previous study of a variety of human tumors… CONTINUE READING

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