• Corpus ID: 13508470

Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.

  title={Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.},
  author={Tsutomu Shimada and Carrie L. Hayes and Hiroshi Yamazaki and Shantu Amin and Stephen S. Hecht and F. Peter Guengerich and Thomas R. Sutter},
  journal={Cancer research},
  volume={56 13},
A human cytochrome P-450 (P450) 1B1 cDNA was expressed in Saccharomyces cerevisiae and the microsomes containing P450 1B1 were used to examine the selectivity of this enzyme in the activation of a variety of environmental carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002 or NM2009 tester strains, using the SOS response as an end point of DNA damage. We also determined and compared these activities of P450 1B1 with those catalyzed by recombinant human P450s 1A1 and 1A2, which… 

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