Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair.


Accumulation of 8-oxo-7,8-dihydroguanine (8-oxoG) in the DNA results in genetic instability and mutagenesis, and is believed to contribute to carcinogenesis, aging processes and various aging-related diseases. 8-OxoG is removed from the DNA via DNA base excision repair (BER), initiated by 8-oxoguanine DNA glycosylase-1 (OGG1). Our recent studies have shown… (More)
DOI: 10.1016/j.dnarep.2013.06.006