Activation of cell-mediated immunity in depression: association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression.

@article{Maes2012ActivationOC,
  title={Activation of cell-mediated immunity in depression: association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression.},
  author={Michael Maes and Ivana Mihaylova and Marta Kubera and Karl Peter Ringel},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2012},
  volume={36 1},
  pages={169-75}
}
BACKGROUND Depression is characterized by activation of cell-mediated immunity (CMI), including increased neopterin levels, and increased pro-inflammatory cytokines (PICs), such as interleukin-1 (IL-1) and tumor necrosis factor-α (TNFα). These PICs may induce depressive, melancholic and chronic fatigue (CF) symptoms. METHODS We examined serum neopterin and plasma PIC levels in depressive subgroups in relation to the depressive subtypes and the melancholic and CF symptoms of depression… CONTINUE READING
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