Activation of caspase-3 in developmental models of programmed cell death in neurons of the substantia nigra.

@article{Jeon1999ActivationOC,
  title={Activation of caspase-3 in developmental models of programmed cell death in neurons of the substantia nigra.},
  author={Beom Suk Jeon and Nikolai G Kholodilov and Tinmarla Frances Oo and Sun Yeou Kim and Kevin J. Tomaselli and Anu Srinivasan and Leonidas Stefanis and Robert E Burke},
  journal={Journal of neurochemistry},
  year={1999},
  volume={73 1},
  pages={322-33}
}
Programmed cell death has been proposed to play a role in the death of neurons in acute and chronic degenerative neurologic disease. There is now evidence that the caspases, a family of cysteine proteases, mediate programmed cell death in various cells. In neurons, caspase-3 (CPP32/Yama/apopain), in particular, has been proposed to play a role. We examined the expression of caspase-3 in three models of programmed cell death affecting neurons of the substantia nigra in the rat: natural… CONTINUE READING
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