Activation of cardiorenal and pulmonary tissue endothelin-1 in experimental heart failure.

  title={Activation of cardiorenal and pulmonary tissue endothelin-1 in experimental heart failure.},
  author={Andreas Luchner and Michihisa Jougasaki and Eckhard Friedrich and Daniel D Borgeson and Tracy L Stevens and Margaret M. Redfield and G A Riegger and John C. Burnett},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={279 3},
Endothelin-1 (ET-1) is a peptide that has been implicated in congestive heart failure (CHF). Although increased concentrations of circulating ET-1 have been repeatedly demonstrated, the activation of local ET-1 in target tissues of CHF remains poorly defined. Our objective was to characterize ET-1 tissue concentrations and gene expression of prepro ET-1 in myocardial, renal, and pulmonary tissue in rapid ventricular pacing-induced canine CHF. Progressive rapid ventricular pacing (38 days… CONTINUE READING
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Enhanced atrial and pulmonary endothelin synthesis in a canine model of chronic low output

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